The Effect of Zinc and D-Penicillamine in a Stable Human Hepatoma ATP7B Knockout Cell Line

Mutations in the copper (Cu) transporter gene ATP7B, the primary cause of Wilson disease (WD), result in high liver Cu and death of hepatocytes. Cu chelators and zinc salts are the two most important drugs used in the treatment of WD patients; however, the molecular mechanisms of the drugs with rega...

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Detalles Bibliográficos
Autores principales: Chandhok, Gursimran, Schmitt, Nadine, Sauer, Vanessa, Aggarwal, Annu, Bhatt, Mohit, Schmidt, Hartmut H. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044041/
https://www.ncbi.nlm.nih.gov/pubmed/24892424
http://dx.doi.org/10.1371/journal.pone.0098809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044041/
https://www.ncbi.nlm.nih.gov/pubmed/24892424
http://dx.doi.org/10.1371/journal.pone.0098809

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