Degradation of mutant p53H175 protein by Zn(II) through autophagy

TP53, one of the most important oncosuppressors, is frequently mutated in cancer. Several p53 mutant proteins escape proteolytic degradation and are highly expressed in an aberrant conformation often acquiring pro-oncogenic activities that promote tumor progression and resistance to therapy. Therefo...

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Detalles Bibliográficos
Autores principales: Garufi, A, Pucci, D, D'Orazi, V, Cirone, M, Bossi, G, Avantaggiati, M L, D'Orazi, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044866/
https://www.ncbi.nlm.nih.gov/pubmed/24874727
http://dx.doi.org/10.1038/cddis.2014.217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044866/
https://www.ncbi.nlm.nih.gov/pubmed/24874727
http://dx.doi.org/10.1038/cddis.2014.217

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