Preclinical studies of N(3)-O-toluyl-fluorouracil-loaded lipid-based nanosuspensions in H(22)-bearing mice

PURPOSE: N(3)-O-toluyl-fluorouracil (TFU) is a potential antitumor prodrug of 5-fluorouracil (5-FU), but its poor solubility has limited its use in clinic. This study aimed to improve the bioavailability of TFU by preparing TFU-loaded lipid-based nanosuspensions (TFU-LNS) and perform a preclinical e...

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Detalles Bibliográficos
Autores principales: Zhang, Juan, Li, Min, Liu, Zhihong, Wang, Lili, Liu, Yongjun, Zhang, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045086/
https://www.ncbi.nlm.nih.gov/pubmed/24920908
http://dx.doi.org/10.2147/IJN.S59338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045086/
https://www.ncbi.nlm.nih.gov/pubmed/24920908
http://dx.doi.org/10.2147/IJN.S59338

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