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Preclinical studies of N(3)-O-toluyl-fluorouracil-loaded lipid-based nanosuspensions in H(22)-bearing mice
PURPOSE: N(3)-O-toluyl-fluorouracil (TFU) is a potential antitumor prodrug of 5-fluorouracil (5-FU), but its poor solubility has limited its use in clinic. This study aimed to improve the bioavailability of TFU by preparing TFU-loaded lipid-based nanosuspensions (TFU-LNS) and perform a preclinical e...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045086/ https://www.ncbi.nlm.nih.gov/pubmed/24920908 http://dx.doi.org/10.2147/IJN.S59338 |