Unusual Characteristics of the DNA Binding Domain of Epigenetic Regulatory Protein MeCP2 Determine Its Binding Specificity

[Image: see text] The protein MeCP2 mediates epigenetic regulation by binding methyl-CpG (mCpG) sites on chromatin. MeCP2 consists of six domains of which one, the methyl binding domain (MBD), binds mCpG sites in duplex DNA. We show that solution conditions with physiological or greater salt concent...

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Detalles Bibliográficos
Autores principales: Khrapunov, Sergei, Warren, Christopher, Cheng, Huiyong, Berko, Esther R., Greally, John M., Brenowitz, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045320/
https://www.ncbi.nlm.nih.gov/pubmed/24828757
http://dx.doi.org/10.1021/bi500424z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045320/
https://www.ncbi.nlm.nih.gov/pubmed/24828757
http://dx.doi.org/10.1021/bi500424z

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