IL-10 modulates DSS-induced colitis through a macrophage – ROS – NO axis

Breakdown of the epithelial barrier due to toxins or other insults leads to severe colitis. IL-10 is a critical regulator of this, yet its cellular targets and mechanisms of action are not resolved. We address this here. Mice with a macrophage-selective deletion of IL-10Rα (IL-10Rα(Mdel)) developed...

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Detalles Bibliográficos
Autores principales: Li, Bofeng, Alli, Rajshekhar, Vogel, Peter, Geiger, Terrence L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045662/
https://www.ncbi.nlm.nih.gov/pubmed/24301657
http://dx.doi.org/10.1038/mi.2013.103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045662/
https://www.ncbi.nlm.nih.gov/pubmed/24301657
http://dx.doi.org/10.1038/mi.2013.103

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