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IL-10 modulates DSS-induced colitis through a macrophage – ROS – NO axis
Breakdown of the epithelial barrier due to toxins or other insults leads to severe colitis. IL-10 is a critical regulator of this, yet its cellular targets and mechanisms of action are not resolved. We address this here. Mice with a macrophage-selective deletion of IL-10Rα (IL-10Rα(Mdel)) developed...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045662/ https://www.ncbi.nlm.nih.gov/pubmed/24301657 http://dx.doi.org/10.1038/mi.2013.103 |