Sirt1 Deletion Leads to Enhanced Inflammation and Aggravates Endotoxin-Induced Acute Kidney Injury

Bacterial endotoxin has been known to induce excessive inflammatory responses and acute kidney injury. In the present study, we used a mouse model of endotoxemia to investigate the role of Sirt1 in inflammatory kidney injury. We examined molecular and cellular responses in inducible Sirt1 knockout (...

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Detalles Bibliográficos
Autores principales: Gao, Rong, Chen, Jiao, Hu, Yuxin, Li, Zhenyu, Wang, Shuxia, Shetty, Sreerama, Fu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045768/
https://www.ncbi.nlm.nih.gov/pubmed/24896770
http://dx.doi.org/10.1371/journal.pone.0098909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045768/
https://www.ncbi.nlm.nih.gov/pubmed/24896770
http://dx.doi.org/10.1371/journal.pone.0098909

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