Kinetic Validation of the Models for P-Glycoprotein ATP Hydrolysis and Vanadate-Induced Trapping. Proposal for Additional Steps

P-Glycoprotein, a member of the ATP-binding cassette (ABC) superfamily, is a multidrug transporter responsible for cellular efflux of hundreds of structurally unrelated compounds, including natural products, many clinically used drugs and anti-cancer agents. Expression of P-glycoprotein has been lin...

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Detalles Bibliográficos
Autores principales: Lugo, Miguel Ramón, Sharom, Frances Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045855/
https://www.ncbi.nlm.nih.gov/pubmed/24897122
http://dx.doi.org/10.1371/journal.pone.0098804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045855/
https://www.ncbi.nlm.nih.gov/pubmed/24897122
http://dx.doi.org/10.1371/journal.pone.0098804

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