Comparative examination of various PCR-based methods for DNMT3A and IDH1/2 mutations identification in acute myeloid leukemia

BACKGROUND: Mutations in epigenetic modifiers were reported in patients with acute myeloid leukaemia (AML) including mutations in DNA methyltransferase 3A gene (DNMT3A) in 20%-30% patients and mutations in isocitrate dehydrogenase 1/2 gene (IDH1/2) in 5%-15% patients. Novel studies have shown that m...

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Detalles Bibliográficos
Autores principales: Berenstein, Rimma, Blau, Igor Wolfgang, Kar, Asiye, Cay, Ruhiye, Sindram, Annette, Seide, Claudia, Blau, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045877/
https://www.ncbi.nlm.nih.gov/pubmed/24887327
http://dx.doi.org/10.1186/1756-9966-33-44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045877/
https://www.ncbi.nlm.nih.gov/pubmed/24887327
http://dx.doi.org/10.1186/1756-9966-33-44

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