Diazoxide protects against doxorubicin-induced cardiotoxicity in the rat

AIM: Chemotherapy with doxorubicin is limited by cardiotoxicity. Free radical generation and mitochondrial dysfunction are thought to contribute to doxorubicin-induced cardiac failure. In this study we wanted to investigate if opening of mitochondrial K(ATP)-channels by diazoxide is protective again...

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Detalles Bibliográficos
Autores principales: Hole, Lisa Drange, Larsen, Terje Hjalmar, Fossan, Kjell Ove, Limé, Fredrik, Schjøtt, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045949/
https://www.ncbi.nlm.nih.gov/pubmed/24887454
http://dx.doi.org/10.1186/2050-6511-15-28

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