Transcription Factor Ets1 Regulates Expression of Thioredoxin-Interacting Protein and Inhibits Insulin Secretion in Pancreatic β-Cells

Long-term activation of extracellular-regulated kinase (ERK1/2) pathway has been shown to cause glucotoxicity and inhibit insulin gene expression in β-cells. Transcription factor Ets1 is activated by ERK1/2-mediated phosphorylation at the Thr38 residue. We hypothesize that Ets1 plays an important ro...

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Detalles Bibliográficos
Autores principales: Luo, Yan, He, Fengli, Hu, Li, Hai, Luo, Huang, Meifeng, Xu, Zhipeng, Zhang, Jingjing, Zhou, Zhiguang, Liu, Feng, Dai, Yan-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045976/
https://www.ncbi.nlm.nih.gov/pubmed/24897113
http://dx.doi.org/10.1371/journal.pone.0099049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045976/
https://www.ncbi.nlm.nih.gov/pubmed/24897113
http://dx.doi.org/10.1371/journal.pone.0099049

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