Two M-T hook residues greatly improve the antiviral activity and resistance profile of the HIV-1 fusion inhibitor SC29EK

BACKGROUND: Peptides derived from the C-terminal heptad repeat (CHR) of HIV-1 gp41 such as T20 (Enfuvirtide) and C34 are potent viral fusion inhibitors. We have recently found that two N-terminal residues (Met115 and Thr116) of CHR peptides form a unique M-T hook structure that can greatly enhance t...

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Detalles Bibliográficos
Autores principales: Chong, Huihui, Qiu, Zonglin, Sun, Jianping, Qiao, Yuanyuan, Li, Xingxing, He, Yuxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046051/
https://www.ncbi.nlm.nih.gov/pubmed/24884671
http://dx.doi.org/10.1186/1742-4690-11-40

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046051/
https://www.ncbi.nlm.nih.gov/pubmed/24884671
http://dx.doi.org/10.1186/1742-4690-11-40

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