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eIF2B is a decameric guanine nucleotide exchange factor with a γ(2)ε(2) tetrameric core
eIF2B facilitates and controls protein synthesis in eukaryotes by mediating guanine nucleotide exchange on its partner eIF2. We combined mass spectrometry (MS) with chemical cross-linking, surface accessibility measurements and homology modelling to define subunit stoichiometry and interactions with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046112/ https://www.ncbi.nlm.nih.gov/pubmed/24852487 http://dx.doi.org/10.1038/ncomms4902 |