Metabolic engineering of lactate dehydrogenase rescues mice from acidosis

Acidosis causes millions of deaths each year and strategies for normalizing the blood pH in acidosis patients are greatly needed. The lactate dehydrogenase (LDH) pathway has great potential for treating acidosis due to its ability to convert protons and pyruvate into lactate and thereby raise blood...

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Detalles Bibliográficos
Autores principales: Acharya, Abhinav P., Rafi, Mohammad, Woods, Elliot C., Gardner, Austin B., Murthy, Niren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046128/
https://www.ncbi.nlm.nih.gov/pubmed/24898534
http://dx.doi.org/10.1038/srep05189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046128/
https://www.ncbi.nlm.nih.gov/pubmed/24898534
http://dx.doi.org/10.1038/srep05189

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