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Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo

BACKGROUND: One of the main features of Alzheimer’s disease (AD) is the presence of Aβ deposits, which accumulate in the brain years before the onset of symptoms. We and others have demonstrated that cerebral Aβ-amyloidosis can be induced in vivo by administration of AD-brain extracts into transgeni...

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Autores principales: Duran-Aniotz, Claudia, Morales, Rodrigo, Moreno-Gonzalez, Ines, Hu, Ping Ping, Soto, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046659/
https://www.ncbi.nlm.nih.gov/pubmed/24252208
http://dx.doi.org/10.1186/2051-5960-1-76
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author Duran-Aniotz, Claudia
Morales, Rodrigo
Moreno-Gonzalez, Ines
Hu, Ping Ping
Soto, Claudio
author_facet Duran-Aniotz, Claudia
Morales, Rodrigo
Moreno-Gonzalez, Ines
Hu, Ping Ping
Soto, Claudio
author_sort Duran-Aniotz, Claudia
collection PubMed
description BACKGROUND: One of the main features of Alzheimer’s disease (AD) is the presence of Aβ deposits, which accumulate in the brain years before the onset of symptoms. We and others have demonstrated that cerebral Aβ-amyloidosis can be induced in vivo by administration of AD-brain extracts into transgenic mice. However, it is currently unknown whether amyloid formation can be induced using extracts from individuals harboring Aβ deposits, but not clinical disease. RESULTS: In this study we analyzed the amyloid-inducing capability of samples from individuals affected by mild cognitive impairment (MCI) and Non-Demented persons with Alzheimer’s disease Neuropathology (NDAN). Our results show that inoculation of transgenic mice with MCI and NDAN brain samples accelerated Aβ pathology in a similar way as extracts from confirmed AD. CONCLUSIONS: This data demonstrate that the sole presence of Aβ aggregates in a given sample, regardless of the clinical condition, is capable to accelerate Aβ deposition in vivo. These findings indicate that the amyloid-inducing activity may be present in the brain of people during pre-symptomatic or a-symptomatic stages of AD.
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spelling pubmed-40466592014-06-06 Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo Duran-Aniotz, Claudia Morales, Rodrigo Moreno-Gonzalez, Ines Hu, Ping Ping Soto, Claudio Acta Neuropathol Commun Research BACKGROUND: One of the main features of Alzheimer’s disease (AD) is the presence of Aβ deposits, which accumulate in the brain years before the onset of symptoms. We and others have demonstrated that cerebral Aβ-amyloidosis can be induced in vivo by administration of AD-brain extracts into transgenic mice. However, it is currently unknown whether amyloid formation can be induced using extracts from individuals harboring Aβ deposits, but not clinical disease. RESULTS: In this study we analyzed the amyloid-inducing capability of samples from individuals affected by mild cognitive impairment (MCI) and Non-Demented persons with Alzheimer’s disease Neuropathology (NDAN). Our results show that inoculation of transgenic mice with MCI and NDAN brain samples accelerated Aβ pathology in a similar way as extracts from confirmed AD. CONCLUSIONS: This data demonstrate that the sole presence of Aβ aggregates in a given sample, regardless of the clinical condition, is capable to accelerate Aβ deposition in vivo. These findings indicate that the amyloid-inducing activity may be present in the brain of people during pre-symptomatic or a-symptomatic stages of AD. BioMed Central 2013-11-18 /pmc/articles/PMC4046659/ /pubmed/24252208 http://dx.doi.org/10.1186/2051-5960-1-76 Text en © Duran-Aniotz et al.; licensee BioMed Central Ltd. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Duran-Aniotz, Claudia
Morales, Rodrigo
Moreno-Gonzalez, Ines
Hu, Ping Ping
Soto, Claudio
Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo
title Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo
title_full Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo
title_fullStr Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo
title_full_unstemmed Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo
title_short Brains from non-Alzheimer’s individuals containing amyloid deposits accelerate Aβ deposition in vivo
title_sort brains from non-alzheimer’s individuals containing amyloid deposits accelerate aβ deposition in vivo
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046659/
https://www.ncbi.nlm.nih.gov/pubmed/24252208
http://dx.doi.org/10.1186/2051-5960-1-76
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