Systematic Domain Swaps of Iterative, Nonreducing Polyketide Synthases Provide a Mechanistic Understanding and Rationale For Catalytic Reprogramming

[Image: see text] Iterative, nonreducing polyketide synthases (NR-PKSs) are multidomain enzymes responsible for the construction of the core architecture of aromatic polyketide natural products in fungi. Engineering these enzymes for the production of non-native metabolites has been a long-standing...

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Detalles Bibliográficos
Autores principales: Newman, Adam G., Vagstad, Anna L., Storm, Philip A., Townsend, Craig A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046768/
https://www.ncbi.nlm.nih.gov/pubmed/24815013
http://dx.doi.org/10.1021/ja5007299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046768/
https://www.ncbi.nlm.nih.gov/pubmed/24815013
http://dx.doi.org/10.1021/ja5007299

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