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Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases
[Image: see text] The role of protein dynamics in the reaction catalyzed by dihydrofolate reductase from the hyperthermophile Thermotoga maritima (TmDHFR) has been examined by enzyme isotope substitution ((15)N, (13)C, (2)H). In contrast to all other enzyme reactions investigated previously, includi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046772/ https://www.ncbi.nlm.nih.gov/pubmed/24779446 http://dx.doi.org/10.1021/ja502673h |