Cargando…

Biodegradable Polymeric Nanoparticles Show High Efficacy and Specificity at DNA Delivery to Human Glioblastoma in Vitro and in Vivo

[Image: see text] Current glioblastoma therapies are insufficient to prevent tumor recurrence and eventual death. Here, we describe a method to treat malignant glioma by nonviral DNA delivery using biodegradable poly(β-amino ester)s (PBAEs), with a focus on the brain tumor initiating cells (BTICs),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guerrero-Cázares, Hugo, Tzeng, Stephany Y., Young, Noah P., Abutaleb, Ameer O., Quiñones-Hinojosa, Alfredo, Green, Jordan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046784/ https://www.ncbi.nlm.nih.gov/pubmed/24766032 http://dx.doi.org/10.1021/nn501197v

Ejemplares similares

Polymeric nanoparticle‐based delivery of TRAIL DNA for cancer‐specific killing
por: Tzeng, Stephany Y., et al.
Publicado: (2016)

Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy
por: Karlsson, Johan, et al.
Publicado: (2021)

Human Cerebrospinal Fluid Modulates Pathways Promoting Glioblastoma Malignancy
por: Carrano, Anna, et al.
Publicado: (2021)

Biodegradable lipophilic polymeric mRNA nanoparticles for ligand-free targeting of splenic dendritic cells for cancer vaccination
por: Ben-Akiva, Elana, et al.
Publicado: (2023)

Theranostic OCT microneedle for fast ultrahigh-resolution deep-brain imaging and efficient laser ablation in vivo
por: Yuan, Wu, et al.
Publicado: (2020)

A Leak Pathway for Luminal Protons in Endosomes Drives Oncogenic Signaling in Glioblastoma
por: Kondapalli, Kalyan C., et al.
Publicado: (2015)

Influence of Basement Membrane Proteins and Endothelial Cell-Derived Factors on the Morphology of Human Fetal-Derived Astrocytes in 2D
por: Levy, Amanda F., et al.
Publicado: (2014)

Mesenchymal Stem Cells Derived from Adipose Tissue vs Bone Marrow: In Vitro Comparison of Their Tropism towards Gliomas
por: Pendleton, Courtney, et al.
Publicado: (2013)

NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin
por: Schiapparelli, Paula, et al.
Publicado: (2017)

Chitosan-Based Non-viral Gene and Drug Delivery Systems for Brain Cancer
por: Lara-Velazquez, Montserrat, et al.
Publicado: (2020)

Gene delivery for immunoengineering
por: Neshat, Sarah Y, et al.
Publicado: (2020)

The generation of oligodendroglial cells is preserved in the rostral migratory stream during aging
por: Capilla-Gonzalez, Vivian, et al.
Publicado: (2013)

Glioblastoma disrupts the ependymal wall and extracellular matrix structures of the subventricular zone
por: Norton, Emily S., et al.
Publicado: (2022)

Glioblastoma Proximity to the Lateral Ventricle Alters Neurogenic Cell Populations of the Subventricular Zone
por: Ripari, Luisina B., et al.
Publicado: (2021)

Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma
por: Fernandez-Gil, Beatriz I., et al.
Publicado: (2022)

Utilization of biodegradable polymeric materials as delivery agents in dermatology
por: Rancan, Fiorenza, et al.
Publicado: (2014)

Enhancing the Delivery of Chemotherapeutics: Role of Biodegradable Polymeric Nanoparticles
por: Ahlawat, Jyoti, et al.
Publicado: (2018)

Biodegradable Polymeric Nanoparticles for Drug Delivery to Solid Tumors
por: Gagliardi, Agnese, et al.
Publicado: (2021)

SERPINA3 in glioblastoma and Alzheimer’s disease
por: Norton, Emily S., et al.
Publicado: (2021)

Polymeric nanoparticles for dual-targeted theranostic gene delivery to hepatocellular carcinoma
por: Vaughan, Hannah J., et al.
Publicado: (2022)

Production of Biodegradable Polymeric Composites with the Addition of Waste
por: da Silva Fernandes, Fernando Antonio, et al.
Publicado: (2023)

Editorial to Special Issue “Glioblastoma: Recapitulating the Key Breakthroughs and Future Perspective”
por: Sharma, Amit, et al.
Publicado: (2023)

Biodegradable Polymeric Microsphere-Based Drug Delivery for Inductive Browning of Fat
por: Jiang, Chunhui, et al.
Publicado: (2015)

Editorial: Biodegradable polymeric materials in tissue engineering and their application in drug delivery
por: Singh, Sudarshan, et al.
Publicado: (2023)

Sex-Specific Differences in Glioblastoma
por: Carrano, Anna, et al.
Publicado: (2021)

A biodegradable polymeric system for peptide–protein delivery assembled with porous microspheres and nanoparticles, using an adsorption/infiltration process
por: Alcalá-Alcalá, Sergio, et al.
Publicado: (2013)

Polymeric Nanoparticles for Nonviral Gene Therapy Extend Brain Tumor Survival in Vivo
por: Mangraviti, Antonella, et al.
Publicado: (2015)

Overcoming delivery barriers in immunotherapy for glioblastoma
por: Rui, Yuan, et al.
Publicado: (2021)

Synthetic poly(ester amine) and poly(amido amine) nanoparticles for efficient DNA and siRNA delivery to human endothelial cells
por: Tzeng, Stephany Y, et al.
Publicado: (2011)

Shear Forces during Blast, Not Abrupt Changes in Pressure Alone, Generate Calcium Activity in Human Brain Cells
por: Ravin, Rea, et al.
Publicado: (2012)

Radio-frequency plasma polymerized biodegradable carrier for in vivo release of cis-platinum
por: Bhatt, Sudhir, et al.
Publicado: (2016)

Biomaterial-Mediated Genetic Reprogramming of Merkel Cell Carcinoma and Melanoma Leads to Targeted Cancer Cell Killing In Vitro and In Vivo
por: Luly, Kathryn M, et al.
Publicado: (2023)

Editorial: Neural Stem Cells of the Subventricular Zone: From Neurogenesis to Glioblastoma Origin
por: Matarredona, Esperanza R., et al.
Publicado: (2021)

Biodegradable Polymeric Architectures via Reversible Deactivation Radical Polymerizations
por: Quan, Fengyu, et al.
Publicado: (2018)

Polymeric Biodegradable Stent Insertion in the Esophagus
por: Yang, Kai, et al.
Publicado: (2016)

Biodegradable Polymeric Materials: Synthetic Approach
por: Panchal, Siddhi S., et al.
Publicado: (2020)

Applications of Novel Biodegradable Polymeric Materials
por: Rydz, Joanna, et al.
Publicado: (2022)

Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151()()
por: Tilghman, Jessica, et al.
Publicado: (2016)

Bioreducible Cationic Polymer-Based Nanoparticles for Efficient and Environmentally Triggered Cytoplasmic siRNA Delivery to Primary Human Brain Cancer Cells
por: Kozielski, Kristen L., et al.
Publicado: (2014)

The endosomal pH regulator NHE9 is a driver of stemness in glioblastoma
por: Ko, Myungjun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_naot8394h1tg07ik7u12lihu20