The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

1. Chronic oxidative stress and inflammation are major mediators of chronic kidney disease (CKD) and result in impaired activation of the cytoprotective transcription factor Nrf2. Given the role of oxidative stress and inflammation in CKD pathogenesis, strategies aimed at restoring Nrf2 activity may...

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Detalles Bibliográficos
Autores principales: Aminzadeh, Mohammad A., Reisman, Scott A., Vaziri, Nosratola D., Khazaeli, Mahyar, Yuan, Jun, Meyer, Colin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa UK Ltd. 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046874/
https://www.ncbi.nlm.nih.gov/pubmed/24195589
http://dx.doi.org/10.3109/00498254.2013.852705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046874/
https://www.ncbi.nlm.nih.gov/pubmed/24195589
http://dx.doi.org/10.3109/00498254.2013.852705

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