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PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila
Two genes linked to early onset Parkinson's disease, PINK1 and Parkin, encode a protein kinase and a ubiquitin-ligase, respectively. Both enzymes have been suggested to support mitochondrial quality control. We have reported that Parkin is phosphorylated at Ser65 within the ubiquitin-like domai...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046931/ https://www.ncbi.nlm.nih.gov/pubmed/24901221 http://dx.doi.org/10.1371/journal.pgen.1004391 |