Adaptor Protein Complexes AP-1 and AP-3 Are Required by the HHV-7 Immunoevasin U21 for Rerouting of Class I MHC Molecules to the Lysosomal Compartment

The human herpesvirus-7 (HHV-7) U21 gene product binds to class I major histocompatibility complex (MHC) molecules and reroutes them to a lysosomal compartment. Trafficking of integral membrane proteins to lysosomes is mediated through cytoplasmic sorting signals that recruit heterotetrameric clathr...

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Detalles Bibliográficos
Autores principales: Kimpler, Lisa A., Glosson, Nicole L., Downs, Deanna, Gonyo, Patrick, May, Nathan A., Hudson, Amy W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047081/
https://www.ncbi.nlm.nih.gov/pubmed/24901711
http://dx.doi.org/10.1371/journal.pone.0099139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047081/
https://www.ncbi.nlm.nih.gov/pubmed/24901711
http://dx.doi.org/10.1371/journal.pone.0099139

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