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Adaptor Protein Complexes AP-1 and AP-3 Are Required by the HHV-7 Immunoevasin U21 for Rerouting of Class I MHC Molecules to the Lysosomal Compartment
The human herpesvirus-7 (HHV-7) U21 gene product binds to class I major histocompatibility complex (MHC) molecules and reroutes them to a lysosomal compartment. Trafficking of integral membrane proteins to lysosomes is mediated through cytoplasmic sorting signals that recruit heterotetrameric clathr...
Autores principales: | Kimpler, Lisa A., Glosson, Nicole L., Downs, Deanna, Gonyo, Patrick, May, Nathan A., Hudson, Amy W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047081/ https://www.ncbi.nlm.nih.gov/pubmed/24901711 http://dx.doi.org/10.1371/journal.pone.0099139 |
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