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Acidic Amino Acids in the First Intracellular Loop Contribute to Voltage- and Calcium- Dependent Gating of Anoctamin1/TMEM16A
Anoctamin1 (Ano1, or TMEM16A) is a Ca(2+)-activated chloride channel that is gated by both voltage and Ca(2+). We have previously identified that the first intracellular loop that contains a high density of acidic residues mediates voltage- and calcium-dependent gating of Ano1. Mutation of the four...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047086/ https://www.ncbi.nlm.nih.gov/pubmed/24901998 http://dx.doi.org/10.1371/journal.pone.0099376 |