A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors

A new paullone–TEMPO conjugate and its copper(ii) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.

Detalles Bibliográficos
Autores principales: Dobrov, Anatolie, Göschl, Simone, Jakupec, Michael A., Popović-Bijelić, Ana, Gräslund, Astrid, Rapta, Peter, Arion, Vladimir B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2013
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047831/
https://www.ncbi.nlm.nih.gov/pubmed/24042148
http://dx.doi.org/10.1039/c3cc45743e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047831/
https://www.ncbi.nlm.nih.gov/pubmed/24042148
http://dx.doi.org/10.1039/c3cc45743e

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