A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors

A new paullone–TEMPO conjugate and its copper(ii) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.

Detalles Bibliográficos
Autores principales: Dobrov, Anatolie, Göschl, Simone, Jakupec, Michael A., Popović-Bijelić, Ana, Gräslund, Astrid, Rapta, Peter, Arion, Vladimir B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2013
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047831/
https://www.ncbi.nlm.nih.gov/pubmed/24042148
http://dx.doi.org/10.1039/c3cc45743e
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author Dobrov, Anatolie
Göschl, Simone
Jakupec, Michael A.
Popović-Bijelić, Ana
Gräslund, Astrid
Rapta, Peter
Arion, Vladimir B.
author_facet Dobrov, Anatolie
Göschl, Simone
Jakupec, Michael A.
Popović-Bijelić, Ana
Gräslund, Astrid
Rapta, Peter
Arion, Vladimir B.
author_sort Dobrov, Anatolie
collection PubMed
description A new paullone–TEMPO conjugate and its copper(ii) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.
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spelling pubmed-40478312014-06-06 A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors Dobrov, Anatolie Göschl, Simone Jakupec, Michael A. Popović-Bijelić, Ana Gräslund, Astrid Rapta, Peter Arion, Vladimir B. Chem Commun (Camb) Chemistry A new paullone–TEMPO conjugate and its copper(ii) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines. Royal Society of Chemistry 2013-11-04 2013-09-17 /pmc/articles/PMC4047831/ /pubmed/24042148 http://dx.doi.org/10.1039/c3cc45743e Text en This journal is © The Royal Society of Chemistry 2013 http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Dobrov, Anatolie
Göschl, Simone
Jakupec, Michael A.
Popović-Bijelić, Ana
Gräslund, Astrid
Rapta, Peter
Arion, Vladimir B.
A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors
title A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors
title_full A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors
title_fullStr A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors
title_full_unstemmed A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors
title_short A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors
title_sort highly cytotoxic modified paullone ligand bearing a tempo free-radical unit and its copper(ii) complex as potential hr2 rnr inhibitors
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047831/
https://www.ncbi.nlm.nih.gov/pubmed/24042148
http://dx.doi.org/10.1039/c3cc45743e
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