Cargando…

A highly cytotoxic modified paullone ligand bearing a TEMPO free-radical unit and its copper(ii) complex as potential hR2 RNR inhibitors

A new paullone–TEMPO conjugate and its copper(ii) complex inhibit RNR activity and show high antiproliferative activity in human cancer cell lines.

Detalles Bibliográficos
Autores principales:	Dobrov, Anatolie, Göschl, Simone, Jakupec, Michael A., Popović-Bijelić, Ana, Gräslund, Astrid, Rapta, Peter, Arion, Vladimir B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2013
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047831/ https://www.ncbi.nlm.nih.gov/pubmed/24042148 http://dx.doi.org/10.1039/c3cc45743e

Ejemplares similares

The Release of a Highly Cytotoxic Paullone Bearing a TEMPO Free Radical from the HSA Hydrogel: An EPR Spectroscopic Characterization
por: Vesković, Ana, et al.
Publicado: (2022)

Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity
por: Stepanenko, Iryna, et al.
Publicado: (2021)

Triapine Analogues and Their Copper(II) Complexes: Synthesis, Characterization, Solution Speciation, Redox Activity, Cytotoxicity, and mR2 RNR Inhibition
por: Besleaga, Iuliana, et al.
Publicado: (2021)

Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells
por: Mühlgassner, Gerhard, et al.
Publicado: (2012)

Binding of a Fatty Acid-Functionalized Anderson-Type Polyoxometalate to Human Serum Albumin
por: Bijelic, Aleksandar, et al.
Publicado: (2020)

A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant
por: Rozman Grinberg, Inna, et al.
Publicado: (2018)

Iron(II) and copper(II) paratungstates B: a single-crystal X-ray diffraction study
por: Gumerova, Nadiia I., et al.
Publicado: (2018)

Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres
por: Maicher, André, et al.
Publicado: (2017)

An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones
por: Aksenov, Dmitrii A., et al.
Publicado: (2023)

The indole motif is essential for the antitrypanosomal activity of N(5)-substituted paullones
por: Ihnatenko, Irina, et al.
Publicado: (2023)

Ruthenium- and osmium-arene complexes of 8-substituted indolo[3,2-c]quinolines: Synthesis, X-ray diffraction structures, spectroscopic properties, and antiproliferative activity
por: Filak, Lukas K., et al.
Publicado: (2012)

Triapine Derivatives Act as Copper Delivery Vehicles to Induce Deadly Metal Overload in Cancer Cells
por: Ohui, Kateryna, et al.
Publicado: (2020)

Diastereomeric dinickel(ii) complexes with non-innocent bis(octaazamacrocyclic) ligands: isomerization, spectroelectrochemistry, DFT calculations and use in catalytic oxidation of cyclohexane
por: Dobrov, Anatolie, et al.
Publicado: (2022)

Dicopper(II) and Dizinc(II) Complexes with Nonsymmetric Dinucleating Ligands Based on Indolo[3,2-c]quinolines: Synthesis, Structure, Cytotoxicity, and Intracellular Distribution
por: Primik, Michael F., et al.
Publicado: (2013)

Mechanistic and biological characterisation of novel N(5)-substituted paullones targeting the biosynthesis of trypanothione in Leishmania
por: Medeiros, Andrea, et al.
Publicado: (2020)

RNR1, a 3′–5′ exoribonuclease belonging to the RNR superfamily, catalyzes 3′ maturation of chloroplast ribosomal RNAs in Arabidopsis thaliana
por: Bollenbach, Thomas J., et al.
Publicado: (2005)

New Water-Soluble Copper(II) Complexes with Morpholine–Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action
por: Ohui, Kateryna, et al.
Publicado: (2018)

Reverse Engineering the Yeast RNR1 Transcriptional Control System
por: Mao, Grace, et al.
Publicado: (2010)

Synthesis of a TEMPO-Substituted Polyacrylamide Bearing a Sulfonate Sodium Pendant and Its Properties in an Organic Radical Battery
por: Zhu, Junfeng, et al.
Publicado: (2019)

Assessing the reliability and validity of the Risk-Need-Responsivity (RNR) program tool
por: Ramezani, Niloofar, et al.
Publicado: (2022)

Tempo of magma degassing and the genesis of porphyry copper deposits
por: Chelle-Michou, Cyril, et al.
Publicado: (2017)

The Hydrates of TEMPO: Water Vibrations Reveal Radical Microsolvation
por: Brás, Elisa M., et al.
Publicado: (2021)

Spectroscopic Characterization of the Binding and Release of Hydrophilic, Hydrophobic and Amphiphilic Molecules from Ovalbumin Supramolecular Hydrogels
por: Vesković, Ana, et al.
Publicado: (2022)

Checkpoint-dependent RNR induction promotes fork restart after replicative stress
por: Morafraile, Esther C., et al.
Publicado: (2015)

RNR-R2 Upregulation by a Short Non-Coding Viral Transcript
por: Broennimann, Karin, et al.
Publicado: (2021)

Correction: Assessing the reliability and validity of the Risk-Need-Responsivity (RNR) program tool
por: Ramezani, Niloofar, et al.
Publicado: (2022)

Electrochemical Alcohol Oxidation Mediated by TEMPO‐like Nitroxyl Radicals
por: Ciriminna, Rosaria, et al.
Publicado: (2017)

Metal–Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation
por: Filak, Lukas K., et al.
Publicado: (2013)

Targeted Release in the COVID-19 Correctional Crisis: Using the RNR Model to Save Lives
por: Vose, Brenda, et al.
Publicado: (2020)

Impact of an MT-RNR1 Gene Polymorphism on Hepatocellular Carcinoma Progression and Clinical Characteristics
por: Lin, Yang-Hsiang, et al.
Publicado: (2021)

Elucidation of Structure–Activity Relationships in Indolobenzazepine-Derived Ligands and Their Copper(II) Complexes: the Role of Key Structural Components and Insight into the Mechanism of Action
por: Kuznetcova, Irina, et al.
Publicado: (2022)

DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4–Not complex
por: Mulder, Klaas W., et al.
Publicado: (2005)

Ixr1 Is Required for the Expression of the Ribonucleotide Reductase Rnr1 and Maintenance of dNTP Pools
por: Tsaponina, Olga, et al.
Publicado: (2011)

Functional link between mitochondria and Rnr3, the minor catalytic subunit of yeast ribonucleotide reductase
por: Corcoles-Saez, Isaac, et al.
Publicado: (2019)

Mechanochemical and slow-chemistry radical transformations: a case of diorganozinc compounds and TEMPO
por: Budny-Godlewski, Krzysztof, et al.
Publicado: (2019)

Arynes as Radical Acceptors: TEMPO‐Mediated Cascades Comprising Addition, Cyclization, and Trapping
por: Scherübl, Maximilian, et al.
Publicado: (2020)

Preparation of Xanthene-TEMPO Dyads: Synthesis and Study of the Radical Enhanced Intersystem Crossing
por: Zhu, Wenhui, et al.
Publicado: (2023)

Ruthenium-Nitrosyl Complexes with Glycine, l-Alanine, l-Valine, l-Proline, d-Proline, l-Serine, l-Threonine, and l-Tyrosine: Synthesis, X-ray Diffraction Structures, Spectroscopic and Electrochemical Properties, and Antiproliferative Activity
por: Rathgeb, Anna, et al.
Publicado: (2014)

RNR2 repression by p21 restricts reverse transcription of HIV-1 and related-lentiviruses in macrophages
por: Allouch, Awatef, et al.
Publicado: (2013)

Structure and surface analyses of a newly synthesized acyl thiourea derivative along with its in silico and in vitro investigations for RNR, DNA binding, urease inhibition and radical scavenging activities
por: Khalid, Aqsa, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gp63mp9jpp1a88pg4stlja7sju