Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases

Defects in apoptosis are frequently the cause of cancer emergence, as well as cellular resistance to chemotherapy. These phenotypes may be due to mutations of the tumor suppressor TP53 gene. In this study, we examined the effect of various mitotic spindle poisons, including the new isocombretastatin...

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Detalles Bibliográficos
Autores principales: Farhat, M, Poissonnier, A, Hamze, A, Ouk-Martin, C, Brion, J-D, Alami, M, Feuillard, J, Jayat-Vignoles, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047855/
https://www.ncbi.nlm.nih.gov/pubmed/24787013
http://dx.doi.org/10.1038/cddis.2014.150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047855/
https://www.ncbi.nlm.nih.gov/pubmed/24787013
http://dx.doi.org/10.1038/cddis.2014.150

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