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Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases
Defects in apoptosis are frequently the cause of cancer emergence, as well as cellular resistance to chemotherapy. These phenotypes may be due to mutations of the tumor suppressor TP53 gene. In this study, we examined the effect of various mitotic spindle poisons, including the new isocombretastatin...
Autores principales: | Farhat, M, Poissonnier, A, Hamze, A, Ouk-Martin, C, Brion, J-D, Alami, M, Feuillard, J, Jayat-Vignoles, C |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047855/ https://www.ncbi.nlm.nih.gov/pubmed/24787013 http://dx.doi.org/10.1038/cddis.2014.150 |
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