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Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function

The presence of tangles composed of phosphorylated tau is one of the neuropathological hallmarks of Alzheimer's disease (AD). Tau, a microtubule (MT)-associated protein, accumulates in AD potentially as a result of posttranslational modifications, such as hyperphosphorylation and conformational...

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Detalles Bibliográficos
Autores principales: Kim, B M, You, M-H, Chen, C-H, Lee, S, Hong, Y, Kimchi, A, Zhou, X Z, Lee, T H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047864/
https://www.ncbi.nlm.nih.gov/pubmed/24853415
http://dx.doi.org/10.1038/cddis.2014.216