Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium

Mammalian target of rapamycin (mTOR) is involved in insulin resistance (IR) and diabetic retinopathy. In retinal pigment epithelial (RPE) cells, insulin activates the mTOR pathway, inducing hypoxia-inducible factor-1α (HIF-1α) and HIF-dependent transcription in serum-free minimum essential medium Ea...

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Detalles Bibliográficos
Autores principales: Leontieva, O V, Demidenko, Z N, Blagosklonny, M V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047870/
https://www.ncbi.nlm.nih.gov/pubmed/24810050
http://dx.doi.org/10.1038/cddis.2014.178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047870/
https://www.ncbi.nlm.nih.gov/pubmed/24810050
http://dx.doi.org/10.1038/cddis.2014.178

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