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Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium
Mammalian target of rapamycin (mTOR) is involved in insulin resistance (IR) and diabetic retinopathy. In retinal pigment epithelial (RPE) cells, insulin activates the mTOR pathway, inducing hypoxia-inducible factor-1α (HIF-1α) and HIF-dependent transcription in serum-free minimum essential medium Ea...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047870/ https://www.ncbi.nlm.nih.gov/pubmed/24810050 http://dx.doi.org/10.1038/cddis.2014.178 |