Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation

Phospho-Ser129 α-synuclein is the modified form of α-synuclein that occurs most frequently within Parkinson's disease pathological inclusions. Here we demonstrate that the antidiabetic drug metformin significantly reduces levels of phospho-Ser129 α-synuclein and the ratio of phospho-Ser129 α-sy...

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Detalles Bibliográficos
Autores principales: Pérez-Revuelta, B I, Hettich, M M, Ciociaro, A, Rotermund, C, Kahle, P J, Krauss, S, Di Monte, D A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047877/
https://www.ncbi.nlm.nih.gov/pubmed/24810045
http://dx.doi.org/10.1038/cddis.2014.175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047877/
https://www.ncbi.nlm.nih.gov/pubmed/24810045
http://dx.doi.org/10.1038/cddis.2014.175

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