Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner

Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the question of whether NGF can also protect against apoptosis downstream of caspas...

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Detalles Bibliográficos
Autores principales: Mnich, K, Carleton, L A, Kavanagh, E T, Doyle, K M, Samali, A, Gorman, A M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047888/
https://www.ncbi.nlm.nih.gov/pubmed/24787014
http://dx.doi.org/10.1038/cddis.2014.173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047888/
https://www.ncbi.nlm.nih.gov/pubmed/24787014
http://dx.doi.org/10.1038/cddis.2014.173

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