HKH40A downregulates GRP78/BiP expression in cancer cells

HKH40A, the 8-methoxy analog of WMC79, is a synthetic agent with promising in vitro and in vivo antitumor activity, especially against solid tumors. However, molecular mechanisms underlying its antitumor effects are poorly understood. Here, we report that HKH40A markedly reduces the level of GRP78/B...

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Detalles Bibliográficos
Autores principales: Kosakowska-Cholody, T, Lin, J, Srideshikan, S M, Scheffer, L, Tarasova, N I, Acharya, J K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047900/
https://www.ncbi.nlm.nih.gov/pubmed/24853418
http://dx.doi.org/10.1038/cddis.2014.203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047900/
https://www.ncbi.nlm.nih.gov/pubmed/24853418
http://dx.doi.org/10.1038/cddis.2014.203

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