Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells

Glioblastoma multiforme is a devastating disease of the central nervous system and, at present, no effective therapeutic interventions have been identified. Celastrol, a natural occurring triterpene, exhibits potent anti-tumor activity against gliomas in xenograft mouse models. In this study, we des...

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Detalles Bibliográficos
Autores principales: Boridy, S, Le, P U, Petrecca, K, Maysinger, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047902/
https://www.ncbi.nlm.nih.gov/pubmed/24810052
http://dx.doi.org/10.1038/cddis.2014.182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047902/
https://www.ncbi.nlm.nih.gov/pubmed/24810052
http://dx.doi.org/10.1038/cddis.2014.182

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