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Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells

Glioblastoma multiforme is a devastating disease of the central nervous system and, at present, no effective therapeutic interventions have been identified. Celastrol, a natural occurring triterpene, exhibits potent anti-tumor activity against gliomas in xenograft mouse models. In this study, we des...

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Detalles Bibliográficos
Autores principales:	Boridy, S, Le, P U, Petrecca, K, Maysinger, D
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047902/ https://www.ncbi.nlm.nih.gov/pubmed/24810052 http://dx.doi.org/10.1038/cddis.2014.182

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