Chaetocin-induced ROS-mediated apoptosis involves ATM–YAP1 axis and JNK-dependent inhibition of glucose metabolism

Oxidative stress serves as an important regulator of both apoptosis and metabolic reprogramming in tumor cells. Chaetocin, a histone methyltransferase inhibitor, is known to induce ROS generation. As elevating basal ROS level sensitizes glioma cells to apoptosis, the ability of Chaetocin in regulati...

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Detalles Bibliográficos
Autores principales: Dixit, D, Ghildiyal, R, Anto, N P, Sen, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047915/
https://www.ncbi.nlm.nih.gov/pubmed/24810048
http://dx.doi.org/10.1038/cddis.2014.179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047915/
https://www.ncbi.nlm.nih.gov/pubmed/24810048
http://dx.doi.org/10.1038/cddis.2014.179

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