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From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine

Our understanding of the mitochondrial or intrinsic apoptosis pathway and its role in chemotherapy resistance has increased significantly in recent years by a combination of experimental studies and mathematical modelling. This combined approach enhanced the quantitative and kinetic understanding of...

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Detalles Bibliográficos
Autores principales: Würstle, M L, Zink, E, Prehn, J H M, Rehm, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047923/
https://www.ncbi.nlm.nih.gov/pubmed/24874730
http://dx.doi.org/10.1038/cddis.2014.36