Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death

Unlike normal cells, cancer cells contain amplified centrosomes and rely on centrosome clustering mechanisms to form a pseudobipolar spindle that circumvents potentially fatal spindle multipolarity (MP). Centrosome clustering also promotes low-grade chromosome missegregation, which can drive maligna...

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Detalles Bibliográficos
Autores principales: Ogden, A, Cheng, A, Rida, P C G, Pannu, V, Osan, R, Clewley, R, Aneja, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047924/
https://www.ncbi.nlm.nih.gov/pubmed/24787016
http://dx.doi.org/10.1038/cddis.2014.164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047924/
https://www.ncbi.nlm.nih.gov/pubmed/24787016
http://dx.doi.org/10.1038/cddis.2014.164

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