Chronic Hypoxia Promotes Pulmonary Artery Endothelial Cell Proliferation through H(2)O(2)-Induced 5-Lipoxygenase

Pulmonary Hypertension (PH) is a progressive disorder characterized by endothelial dysfunction and proliferation. Hypoxia induces PH by increasing vascular remodeling. A potential mediator in hypoxia-induced PH development is arachidonate 5-Lipoxygenase (ALOX5). While ALOX5 metabolites have been sho...

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Detalles Bibliográficos
Autores principales: Porter, Kristi M., Kang, Bum-Yong, Adesina, Sherry E., Murphy, Tamara C., Hart, C. Michael, Sutliff, Roy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048210/
https://www.ncbi.nlm.nih.gov/pubmed/24906007
http://dx.doi.org/10.1371/journal.pone.0098532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048210/
https://www.ncbi.nlm.nih.gov/pubmed/24906007
http://dx.doi.org/10.1371/journal.pone.0098532

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