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Excessive TGFβ signaling is a common mechanism in Osteogenesis Imperfecta
Osteogenesis Imperfecta (OI) is a heritable disorder of connective tissue characterized by brittle bones, fractures and extraskeletal manifestations(1). How structural mutations of type I collagen (dominant OI) or of its post-translational modification machinery (recessive OI) can cause abnormal qua...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048326/ https://www.ncbi.nlm.nih.gov/pubmed/24793237 http://dx.doi.org/10.1038/nm.3544 |