Excessive TGFβ signaling is a common mechanism in Osteogenesis Imperfecta

Osteogenesis Imperfecta (OI) is a heritable disorder of connective tissue characterized by brittle bones, fractures and extraskeletal manifestations(1). How structural mutations of type I collagen (dominant OI) or of its post-translational modification machinery (recessive OI) can cause abnormal qua...

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Detalles Bibliográficos
Autores principales: Grafe, Ingo, Yang, Tao, Alexander, Stefanie, Homan, Erica, Lietman, Caressa, Jiang, Ming Ming, Bertin, Terry, Munivez, Elda, Chen, Yuqing, Dawson, Brian, Ishikawa, Yoshihiro, Weis, Mary Ann, Sampath, T. Kuber, Ambrose, Catherine, Eyre, David, Bächinger, Hans Peter, Lee, Brendan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048326/
https://www.ncbi.nlm.nih.gov/pubmed/24793237
http://dx.doi.org/10.1038/nm.3544

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