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Gating charge movement precedes ionic current activation in hERG channels

We recently reported gating currents recorded from hERG channels expressed in mammalian TSA cells and assessed the kinetics at different voltages. We detected 2 distinct components of charge movement with the bulk of the charge being carried by a slower component. Here we compare our findings in TSA...

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Detalles Bibliográficos
Autores principales: Goodchild, Samuel J, Fedida, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048346/
https://www.ncbi.nlm.nih.gov/pubmed/24126078
http://dx.doi.org/10.4161/chan.26775