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Dietary Pyridoxine Controls Efficacy of Vitamin B(6)-Auxotrophic Tuberculosis Vaccine Bacillus Calmette-Guérin ΔureC::hly Δpdx1 in Mice

The only tuberculosis (TB) vaccine in use today, bacillus Calmette-Guérin (BCG), provides insufficient protection and can cause adverse events in immunocompromised individuals, such as BCGosis in HIV(+) newborns. We previously reported improved preclinical efficacy and safety of the recombinant vacc...

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Detalles Bibliográficos
Autores principales: Gengenbacher, Martin, Vogelzang, Alexis, Schuerer, Stefanie, Lazar, Doris, Kaiser, Peggy, Kaufmann, Stefan H. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049106/
https://www.ncbi.nlm.nih.gov/pubmed/24895310
http://dx.doi.org/10.1128/mBio.01262-14