Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction

The expansion of homopolymeric glutamine (polyQ) or alanine (polyA) repeats in certain proteins owing to genetic mutations induces protein aggregation and toxicity, causing at least 18 human diseases. PolyQ and polyA repeats can also associate in the same proteins, but the general extent of their as...

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Detalles Bibliográficos
Autores principales: Pelassa, Ilaria, Corà, Davide, Cesano, Federico, Monje, Francisco J., Montarolo, Pier Giorgio, Fiumara, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049302/
https://www.ncbi.nlm.nih.gov/pubmed/24497578
http://dx.doi.org/10.1093/hmg/ddu049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049302/
https://www.ncbi.nlm.nih.gov/pubmed/24497578
http://dx.doi.org/10.1093/hmg/ddu049

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