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Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction
The expansion of homopolymeric glutamine (polyQ) or alanine (polyA) repeats in certain proteins owing to genetic mutations induces protein aggregation and toxicity, causing at least 18 human diseases. PolyQ and polyA repeats can also associate in the same proteins, but the general extent of their as...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049302/ https://www.ncbi.nlm.nih.gov/pubmed/24497578 http://dx.doi.org/10.1093/hmg/ddu049 |