Combined targeting of TGF-β1 and integrin β3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer

BACKGROUND: Transforming Growth Factor beta (TGF-β) acts as a tumor suppressor early in carcinogenesis but turns into tumor promoter in later disease stages. In fact, TGF-β is a known inducer of integrin expression by tumor cells which contributes to cancer metastatic spread and TGF-β inhibition has...

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Detalles Bibliográficos
Autores principales: Salvo, Elizabeth, Garasa, Saray, Dotor, Javier, Morales, Xabier, Peláez, Rafael, Altevogt, Peter, Rouzaut, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049383/
https://www.ncbi.nlm.nih.gov/pubmed/24884715
http://dx.doi.org/10.1186/1476-4598-13-112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049383/
https://www.ncbi.nlm.nih.gov/pubmed/24884715
http://dx.doi.org/10.1186/1476-4598-13-112

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