Fumarate Analogs Act as Allosteric Inhibitors of the Human Mitochondrial NAD(P)(+)-Dependent Malic Enzyme

Human mitochondrial NAD(P)(+)-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic acid in a trans conformation around the carbon-carbon double bond is required for the allosteric...

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Detalles Bibliográficos
Autores principales: Hsieh, Ju-Yi, Liu, Jyung-Hurng, Yang, Pai-Chun, Lin, Chi-Li, Liu, Guang-Yaw, Hung, Hui-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049574/
https://www.ncbi.nlm.nih.gov/pubmed/24911153
http://dx.doi.org/10.1371/journal.pone.0098385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049574/
https://www.ncbi.nlm.nih.gov/pubmed/24911153
http://dx.doi.org/10.1371/journal.pone.0098385

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