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Fumarate Analogs Act as Allosteric Inhibitors of the Human Mitochondrial NAD(P)(+)-Dependent Malic Enzyme
Human mitochondrial NAD(P)(+)-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic acid in a trans conformation around the carbon-carbon double bond is required for the allosteric...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049574/ https://www.ncbi.nlm.nih.gov/pubmed/24911153 http://dx.doi.org/10.1371/journal.pone.0098385 |